In pharmaceutical excipients, pregelatinized starch is a common and important component. It has excellent properties and diverse applications, with microcrystalline cellulose being one of its closely related keywords. This article will detail the application of microcrystalline cellulose in pregelatinized starch pharmaceutical excipients, and discuss its advantages and the development prospects of related fields.

Pregelatinized starch is a specially processed starch with significantly improved solubility and gelatinization properties. Therefore, it has wide applications in the preparation of pharmaceutical excipients. Microcrystalline cellulose, as an auxiliary material, can synergistically interact with pregelatinized starch to further enhance its performance and function.

First, the application of microcrystalline cellulose in pregelatinized starch can improve physical properties. Microcrystalline cellulose has a fibrous structure that can increase the viscosity and stability of starch. This makes the prepared pharmaceutical excipients easier to use and process, and provides better stability and solubility.

Secondly, microcrystalline cellulose can also play a sustained-release and controlled-release role in pregelatinized starch. By adjusting the content and particle size of microcrystalline cellulose, the release rate and time of the drug can be controlled, thereby achieving better therapeutic effects. This is very useful in the preparation of sustained-release drugs and drug forms such as capsules.

In addition, microcrystalline cellulose can also improve the flowability and tableting properties of pregelatinized starch. In the preparation of tablets, the addition of microcrystalline cellulose can increase the binding force between starch particles, making the tablets stronger and more durable. At the same time, the fibrous structure of microcrystalline cellulose can also improve the flowability of pregelatinized starch, reducing clogging and unevenness during the preparation process.

In summary, the application of microcrystalline cellulose in pregelatinized starch pharmaceutical excipients provides many advantages and opportunities for drug preparation and treatment. By improving physical properties, controlling drug efficacy, and improving the preparation process, the synergistic effect of microcrystalline cellulose and pregelatinized starch brings new possibilities for drug research and development and application.

Pregelatinized starch has wide applications in pharmaceutical excipients, and microcrystalline cellulose, as an important auxiliary material, can further enhance its performance and function. The addition of microcrystalline cellulose can improve physical properties, controlled drug release, and the preparation process, providing more advantages and opportunities for drug preparation and treatment.