Pharmaceutical excipient manufacturerPharmaceutical excipients are defined as non-active ingredients in a prescription other than the main drug, or non-active ingredients artificially added in drug preparations other than medicinal materials.

　　In fact, pharmaceutical excipients are the basic materials and important components of drug formulations, playing a crucial role in pharmaceutical processes, drug dosage forms, and drug production. Therefore, it not only gives drugs certain dosage forms, but also has a great impact on the route of administration and product quality, including onset speed, absorption rate, bioavailability, and side effects. In drug formulations, drug activity and physicochemical stability are the main parts, determining the overall efficacy of the formulation. Excipients can achieve the purpose of formulation technology research and development by pharmaceutical excipient manufacturers, ensuring that drugs are released at a certain speed and time in a certain part of the body. Therefore, formulations composed of suitable excipients play a crucial role in the actual application and efficacy of drugs.

　　For example, if the same drug is made into different dosage forms and preparations using different pharmaceutical excipients, the route of administration and mode of action of the drug can be changed, so that the same drug can achieve a variety of different therapeutic purposes.

　　For example, the application of pharmaceutical excipients can enhance the stability of drugs. According to the physicochemical properties of drugs, pharmaceutical excipients with different functions, such as antioxidants, complexing agents, pH adjusters, preservatives, and air displacement agents, are selected in the preparation, or pharmaceutical excipients are selected to prepare new preparations such as prodrug preparations, inclusion complexes, solid dispersions, granules, nanoparticles, and liposomes. Vitamin C, which is easily oxidized and decomposed, is made into microcapsules with ethyl cellulose and other excipients, which is not easy to oxidize, discolor, or deteriorate.

　　Furthermore, pharmaceutical excipients can change the physicochemical properties of drugs, making them change in the direction people need, thereby producing relatively ideal drug formulations.

　　Pharmaceutical excipient manufacturerReminder: Especially for those poorly soluble materials, suitable pharmaceutical excipients can be selected to prepare prodrug preparations or solid dispersions, such as salts, complex salts, esters, and complexes, thereby improving the solubility of the drug. This not only makes the drug easy to absorb, but also changes the route of administration of some drugs. For example, griseofulvin has poor oral absorption, low blood drug concentration, and poor efficacy. After being made into a solid dispersion with polyethylene glycol 6000, it dissolves and absorbs rapidly in the gastrointestinal tract, increasing blood drug concentration and significantly improving systemic antifungal effects.

　　Some drugs with unpleasant odors, volatility, or irritation can be masked or eliminated by adding flavoring agents or by making microcapsules, inclusion complexes, or coated preparations. Plus pharmaceutical excipients. For example, volatile nitroglycerin is made into an inclusion complex preparation with β-cyclodextrin to avoid volatility and enhance stability.

　　According to pharmaceutical excipient manufacturers, the use of appropriate pharmaceutical excipients can enhance or improve the effects and efficacy of the main drug and reduce side effects. A relatively mature method is to use pharmaceutical excipients to prepare new preparations such as prodrug preparations, sustained-release preparations, controlled-release preparations, targeted preparations, and time-controlled preparations. For example, chitosan can reduce the irritation of the anti-inflammatory drug diclofenac sodium to the stomach.