Pre-gelatinized starchIt has a wide range of applications, including extensive use in the pharmaceutical industry. So,Pre-gelatinized starchWhat role does it play in tablet products? The following will provide a detailed explanation to help you understand clearly.

Pre-gelatinized starchAlso known as compressible starch,a-Starch is produced by treating ordinary starch at a temperature above the gelatinization temperature(45℃)to allow the starch to absorb moisture and expand, breaking the hydrogen bonds between molecules and even disrupting the starch granules. Then, the temperature is raised until complete gelatinization occurs. It is then pressed into a film using a fluidized bed dryer and subsequently crushed to obtain the final product. The finished product contains some complete starch granules and some aggregated globules that have been disrupted by water.Pre-gelatinized starchIt is a white, physically modified, powdery substance with certain cold water solubility, and direct compression flowability and binding properties. It is mainly used as a filler, binder in tablets, pills, and granules; binding agent for direct compression; disintegrant. Compared with natural starch,Pre-gelatinized starchit has good flowability and combines binding and disintegration properties; good compressibility with self-lubricating properties; good disintegration properties; solubility in some cold water; it does not react with the main drug and helps stabilize pharmaceutical products.

Pre-gelatinized starchIt not only has good disintegration and binding effects, but also, for pharmaceutical products that are sensitive to moisture and heat, using pre-gelatinized starch can enhance the stability of the active pharmaceutical ingredient, extending the shelf life of the pharmaceutical product. When used for direct compression, compared with commonly used excipients such as microcrystalline cellulose and anhydrous lactose, its compressibility, tablet hardness, and disintegration arePre-gelatinized starchbetter, significantly improving the dissolution of tablets; significantly increasing the hardness of tablets without cracking or fragmentation.